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CTHRC1 is a secreted protein that is cleaved in both in vitro and in vivo conditions, and cleavage may be due to protease activity. We hypothesize that cell injury or cell death is associated with the release of a protease that could cleave CTHRC1, allowing for the generation of active CTHRC1 at sites of tissue injury, including myocardial infarction.
Maine Medical Center, Center for Molecular Medicine, MaineHealth Institute for Research
CTHRC1, Metabolism, Athletic Performance, Medical Research
Toomey, Barbara; Lindner, Volkhard; Kacer, Doreen; and Prudovsky, Igor, "Evidence for CTHRC1 Cleavage and Role in Promoting Metabolic Efficiency: Potential Implications for Endurance Athletic Performance" (2023). Costas T. Lambrew Research Retreat 2023. 9.