Increased myocardial native T1 and extracellular volume in patients with Duchenne muscular dystrophy.
Journal of Cardiovascular Magnetic Resonance (BioMed Central)
Muscular Dystrophy, Duchenne Pathology; Myocardium Pathology; Magnetic Resonance Imaging Methods; Heart Ventricle, Left Pathology; Human; Prospective Studies; Contrast Media; Descriptive Statistics; Nonexperimental Studies; Child; Adolescence; Adult; Data Analysis Software; Random Sample; Wilcoxon Rank Sum Test; Chi Square Test; Fisher's Exact Test; Correlation Coefficient; Ventricular Ejection Fraction; Interrater Reliability; Intrarater Reliability; Male; Tennessee; Funding Source; Child: 6-12 years; Adolescent: 13-18 years; Adult: 19-44 years; Male
Background: Duchenne muscular dystrophy (DMD) cardiomyopathy is a progressive disease for which there is no cure. Disease-specific therapies are needed that can be initiated before irreversible myocardial damage ensues. In order to evaluate therapeutic efficacy, surrogate endpoints other than ejection fraction must be found. The hypothesis of this study is that T1 and extracellular volume fraction (ECV) mapping using cardiovascular magnetic resonance (CMR) can detect diffuse extracellular matrix expansion in DMD patients with normal left ventricular ejection fraction (LVEF) and without myocardial late gadolinium enhancement (LGE). Methods: Thirty-one DMD and 11 healthy control participants were prospectively enrolled. CMR using a modified Look-Locker (MOLLI) sequence was performed in all participants before and after contrast administration. T1 and ECV maps of the mid left ventricular myocardium were generated and regions of interest were contoured using the standard 6-segment AHA model. Global and segmental values were compared between DMD and controls using a Wilcoxon rank-sum test. Results: The DMD participants had significantly higher mean native T1 compared with controls (1045 ms vs 988 ms, p = 0.001). DMD participants with normal LVEF and without evidence of LGE also demonstrated elevated mean native T1 (1039 ms vs 988 ms, p = 0.002, and 1038 ms vs 988 ms, p = 0.011). DMD participants had a significantly greater mean ECV than controls (0.31 vs 0.24, p < 0.001), even in the settings of normal LVEF (0.28 vs 0.24, p < 0.001) and negative LGE (0.29 vs 0.24, p =0.001). Conclusions: DMD participants have elevated LV myocardial native T1 and ECV, even in the setting of normal LVEF and in the absence of LGE. T1 and ECV mapping in DMD have potential to serve as surrogate cardiomyopathy outcome measures for clinical trials.
Soslow, Jonathan H.; Damon, Stephen M.; Crum, Kimberly; Lawson, Mark A.; Slaughter, James C.; Xu, Meng; Arai, Andrew E.; Sawyer, Douglas B.; Parra, David A.; Damon, Bruce M.; and Markham, Larry W., "Increased myocardial native T1 and extracellular volume in patients with Duchenne muscular dystrophy." (2016). Maine Medical Center. 1064.