Title

Bone-fat interaction.

Document Type

Article

Publication Date

3-2017

Institution/Department

MMCRI

Journal Title

Endocrinology and metabolism clinics of North America

ISSN

1558-4410

Abstract

Marrow adipose tissue (MAT) is a recently identified endocrine organ capable of modulating a host of responses. Given its intimate proximity to the bone microenvironment, the impact marrow adipocytes exert on bone has attracted much interest and scientific inquiry. Although many questions and controversies remain about marrow adipocytes, multiple conditions/disease states in which alterations occur have provided clues about their function. The consensus is that MAT is associated inversely with bone density and quality. While further investigation is warranted, MAT has clearly been demonstrated as an active dynamic depot that contributes to bone turnover and overall metabolic homeostasis.

Comments

Maine Medical Research Institute, Scarborough, ME, USA.

First Page

41

Last Page

50

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