Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr
Center for Molecular Medicine, Maine Medical Center Research Institute
Annals of the New York Academy of Sciences
Animals, Blood Glucose, Body Composition, Body Weight, Cardiomyopathies, Cardiotonic Agents, Diabetes Mellitus, Type 2, Diet, Disease Models, Animal, Echocardiography, Female, Insulin, Insulin Resistance, Longevity, Male, Mice, Mice, Inbred C57BL, Sirolimus, Weight Gain
Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardiomyopathy. In view of this, we used a murine model of type 2 diabetes (T2D), BKS-Lepr
Reifsnyder, Peter C; Ryzhov, Sergey; Flurkey, Kevin; Anunciado-Koza, Rea P; Mills, Ian; Harrison, David E; and Koza, Robert A, "Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr" (2018). Maine Medical Center. 1448.