Title

Neoadjuvant Approaches Prior To Radical Prostatectomy.

Document Type

Article

Publication Date

1-1-2020

Journal Title

Cancer journal (Sudbury, Mass.)

MeSH Headings

Male, Neoadjuvant Therapy, Prostatectomy, Prostate, Seminal Vesicles

Abstract

Patients with high-risk localized prostate cancer benefit from multimodality therapy of curative intent. Androgen-deprivation therapy (ADT) combined with radiation improves survival in this population. However, prior clinical trials of neoadjuvant ADT and surgery failed to consistently demonstrate a survival advantage. The development of novel, more potent hormonal agents presents an opportunity to revisit the potential for neoadjuvant therapy to improve long-term outcomes for patients with localized prostate cancer. We review recent advances in neoadjuvant approaches for prostate cancer and emerging clinical trials data supporting the use of neoadjuvant therapy prior to radical prostatectomy.

ISSN

1540-336X

First Page

2

Last Page

12

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