Title

Tumor mitotic rate is an independent predictor of survival for nonmetastatic melanoma.

Document Type

Article

Publication Date

9-1-2018

Institution/Department

Surgery, Oncology, Medical Education

Journal Title

Surgery

MeSH Headings

Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Melanoma, Middle Aged, Mitosis, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, Risk Factors, SEER Program, Skin Neoplasms, Survival Rate, United States, Young Adult

Abstract

BACKGROUND: Tumor mitotic rate is a known prognostic variable in Stage I melanoma; however, its importance is unclear in Stages II and III.

METHODS: Patients diagnosed with nonmetastatic cutaneous melanoma from 2010 to 2014 were identified from the National Cancer Institute's Surveillance, Epidemiology, and End Results registry.

RESULTS: Of a total of 71,235 patients, the majority were white (94.7%), male (58.5%), and had a Stage I tumor (79.0%). On univariable analysis, 5-year disease-specific survival decreased with each increasing tumor mitotic rate category of 0-3, 4-10, and >10 mitoses/mm

CONCLUSION: In this cohort study, tumor mitotic rate is an independent predictor of survival for localized melanoma.

ISSN

1532-7361

First Page

589

Last Page

593

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