Title

The Type 3 Deiodinase: Epigenetic Control of Brain Thyroid Hormone Action and Neurological Function.

Document Type

Article

Publication Date

6-19-2018

Institution/Department

Center for Molecular Medicine, Maine Medical Center Research Institute

Journal Title

Int J Mol Sci

MeSH Headings

Animals, Brain, Genomic Imprinting, Humans, Iodide Peroxidase, Neurodevelopmental Disorders, Thyroid Hormones

Abstract

Thyroid hormones (THs) influence multiple processes in the developing and adult central nervous system, and their local availability needs to be maintained at levels that are tailored to the requirements of their biological targets. The local complement of TH transporters, deiodinase enzymes, and receptors is critical to ensure specific levels of TH action in neural cells. The type 3 iodothyronine deiodinase (DIO3) inactivates THs and is highly present in the developing and adult brain, where it limits their availability and action. DIO3 deficiency in mice results in a host of neurodevelopmental and behavioral abnormalities, demonstrating the deleterious effects of TH excess, and revealing the critical role of DIO3 in the regulation of TH action in the brain. The fact the

ISSN

1422-0067

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