Impact of diet on the persistence of early vascular remodeling and stiffening induced by intrauterine growth restriction and a maternal high-fat diet.
American journal of physiology. Heart and circulatory physiology
Age Factors, Animals, Aorta, Abdominal, Arterial Pressure, Biomarkers, Diet, High-Fat, Disease Models, Animal, Extracellular Matrix, Female, Fetal Growth Retardation, Male, Maternal Nutritional Physiological Phenomena, Nutritional Status, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Sprague-Dawley, Sex Factors, Vascular Remodeling, Vascular Stiffness
Intrauterine growth restriction (IUGR) and maternal high-fat diet (HFD) independently predispose offspring to hypertension. In a rat model, IUGR more so than maternal HFD increases arterial stiffness with vascular remodeling as early as
Miller, Thomas; Dodson, R Blair; Mankouski, Anastasiya; Powers, Kyle N; Yang, Yueqin; Yu, Baifeng; and Zinkhan, Erin K, "Impact of diet on the persistence of early vascular remodeling and stiffening induced by intrauterine growth restriction and a maternal high-fat diet." (2019). Maine Medical Center. 1855.