Title

Impact of diet on the persistence of early vascular remodeling and stiffening induced by intrauterine growth restriction and a maternal high-fat diet.

Document Type

Article

Publication Date

8-1-2019

Institution/Department

Pediatrics, Cardiology

Journal Title

American journal of physiology. Heart and circulatory physiology

MeSH Headings

Age Factors, Animals, Aorta, Abdominal, Arterial Pressure, Biomarkers, Diet, High-Fat, Disease Models, Animal, Extracellular Matrix, Female, Fetal Growth Retardation, Male, Maternal Nutritional Physiological Phenomena, Nutritional Status, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Sprague-Dawley, Sex Factors, Vascular Remodeling, Vascular Stiffness

Abstract

Intrauterine growth restriction (IUGR) and maternal high-fat diet (HFD) independently predispose offspring to hypertension. In a rat model, IUGR more so than maternal HFD increases arterial stiffness with vascular remodeling as early as

ISSN

1522-1539

First Page

424

Last Page

424

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