Novel biological therapies targeting heart failure: myocardial rejuvenation.
Molecular Medicine, MMCRI
Heart failure clinics
Biological Therapy, Genetic Therapy, Heart Failure, Humans, Rejuvenation, Signal Transduction, Stem Cell Transplantation, Translational Medical Research
Recovery of ventricular function occurs in a subset of patients with advanced heart failure treated with medical and/or mechanical therapy. Finding strategies that induce ventricular recovery through induction of repair, regeneration, or "rejuvenation" is a long-sought goal of research programs. Cell-based strategies, use of recombinant growth and survival factors, and gene delivery are under investigation. In this brief article we highlight a few of the biological approaches in development to treat heart failure.
Favreau-Lessard, Amanda J.; Ryzhov, Sergey; and Sawyer, Douglas B., "Novel biological therapies targeting heart failure: myocardial rejuvenation." (2016). Maine Medical Center. 297.