Title

Novel biological therapies targeting heart failure: myocardial rejuvenation.

Document Type

Article

Publication Date

7-2016

Institution/Department

Molecular Medicine, MMCRI

Journal Title

Heart failure clinics

MeSH Headings

Biological Therapy, Genetic Therapy, Heart Failure, Humans, Rejuvenation, Signal Transduction, Stem Cell Transplantation, Translational Medical Research

ISSN

1551-7136

Abstract

Recovery of ventricular function occurs in a subset of patients with advanced heart failure treated with medical and/or mechanical therapy. Finding strategies that induce ventricular recovery through induction of repair, regeneration, or "rejuvenation" is a long-sought goal of research programs. Cell-based strategies, use of recombinant growth and survival factors, and gene delivery are under investigation. In this brief article we highlight a few of the biological approaches in development to treat heart failure.

First Page

461

Last Page

471

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