A perspective on malignancy in the marrow.
Document Type
Article
Publication Date
12-1-2017
Institution/Department
Translational Research, MMCRI
Journal Title
Journal of cellular physiology.
MeSH Headings
Bone Marrow Neoplasms, Humans, Stem Cell Niche, Tissue Engineering
Abstract
Malignancies that grow in the bone marrow cause a cascade of devastating consequences and are almost always fatal. For researchers to make significant headway in finding cures and treatments for these tumors and the subsequent devastation of cancer-induced bone disease, novel strategies and creative solutions will have to be considered. Great progress has been made in treating hematologic and sold tumor malignancies that ultimately affect the bone marrow, although it is also obvious that multi-disciplinary teams are required to ultimately win the war on cancers that affect the bone. In this perspective, we review recent advances in the identification of molecular and cellular targets in the bone marrow niche.
ISSN
1097-4652
First Page
3218
Last Page
3220
Recommended Citation
Reagan, Michaela R; Lian, Jane B; Rosen, Clifford J; and Stein, Gary S, "A perspective on malignancy in the marrow." (2017). Maine Medical Center. 617.
https://knowledgeconnection.mainehealth.org/mmc/617
