A perspective on malignancy in the marrow.
Translational Research, MMCRI
Journal of cellular physiology.
Bone Marrow Neoplasms, Humans, Stem Cell Niche, Tissue Engineering
Malignancies that grow in the bone marrow cause a cascade of devastating consequences and are almost always fatal. For researchers to make significant headway in finding cures and treatments for these tumors and the subsequent devastation of cancer-induced bone disease, novel strategies and creative solutions will have to be considered. Great progress has been made in treating hematologic and sold tumor malignancies that ultimately affect the bone marrow, although it is also obvious that multi-disciplinary teams are required to ultimately win the war on cancers that affect the bone. In this perspective, we review recent advances in the identification of molecular and cellular targets in the bone marrow niche.
Reagan, Michaela R; Lian, Jane B; Rosen, Clifford J; and Stein, Gary S, "A perspective on malignancy in the marrow." (2017). Maine Medical Center. 617.