This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on the role of their signaling pathway in endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagged protein, as well as a substantially purified nucleic acid molecule or segment thereof encoding Jagged protein, or a functionally equivalent derivative, or allelic or species variant thereof.
Maine Medical Center, MaineHealth Institute for Research
Maine Medical Center; Pepper, Michael S.; Montesano, Roberto; Zimrin, Ann B.; Maciag, Thomas; and Wong, Michael, "Therapeutic And Diagnostic Methods And Compositions Based On Jagged/notch Proteins And Nucleic Acids" (2002). MaineHealth Patents. 14.
MaineHealth Institute for Research