Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease.
Case Rep Oncol
Genomics, Urologic Neoplasms, Carcinoma, Transitional Cell
Molecular profiling of urothelial cancers for therapeutic and prognostic potential has been very limited due to the absence of cancer-specific targeted therapies. We describe here 2 clinical cases with a histological diagnosis of an invasive sarcomatoid and a poorly differentiated carcinoma favoring urothelial with some neuroendocrine differentiation, two of the rarer types of urothelial cancers, which were evaluated for mutations in 212 genes for single-nucleotide variants and copy-number variants and 53 genes for fusions associated with solid tumors. In both cases, we identified variants in 2 genes,
Hesse, Andrew N; Fabricius, William; Thomas, Christian A; Gaindh, Ramesh; Christman, Robert; Selvam, Pavalan; Prego, Matthew; Lewis, Gregory; Uvalic, Jasmina; Bergeron, Daniel; Burns, Shelbi; Sisson, Bridgette; Kelly, Kevin; Rueter, Jens; and Reddi, Honey V, "Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease." (2018). Pen Bay Medical Center. 18.