Maine Medical Center, Medical Education, Maine Medical Center Research Institute
Insulin-Like Growth Factor Binding Protein 2, Pilot Projects, Preliminary Data, Gastrectomy, Obesity, Morbid
Vertical Sleeve Gastrectomy (VSG) is a successful treatment for obesity; however, one of the unintended consequences is bone loss. The mechanism behind this side effect is unclear. Insulin-like Growth Factor Binding Protein 2 (IGFBP-2) is necessary for osteoclast proliferation and differentiation. It is one of the most highly expressed proteins in human serum after VSG, and its deletion results in resistance to bone loss in mice. We are interested in determining whether IGFBP2 plays a role in the bone loss observed after VSG. • Pilot study: The main objective of the pilot study is to determine which VSG technique is preferred when performed on mice with respect to survivability and impact on bone. We also aimed to characterize any observed bone changes by examining bone turnover markers after surgery. • Principle Experiment: The main objective of the principle experiment is to determine the impact of VSG on bone loss in Igfbp-2 -/- mice. We also aim to characterize any bone loss.
Pletch, A N.; Harris, B; Le, P T.; and Rosen, Clifford, "Insulin-like Growth Factor Binding Protein 2 May Promote Bone Loss After Vertical Sleeve Gastrectomy: A Pilot Study and Preliminary Data" (2020). Costas T. Lambrew Research Retreat 2020. 22.