Cytokine CXCL2 concentration in the cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage is associated with patient-reported headache pain

Authors

Elizabeth Glisic, Maine Medical Center
Joanne T. deKay, Maine Medical Center Research Institute, Scarborough, ME, USA.
Patricia Lerwick, Department of Critical Care Services, Maine Medical Center, Portland, ME, USA.
David J. Gagnon, Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA.
Richard Riker, Maine Medical Center
Sergey Ryzhov, Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA.

Files

Description

Subarachnoid hemorrhage (SAH) is a severe type of stroke categorized by a sharp, sudden, and persistent headache. The mechanism of headache after SAH is currently poorly understood but the neuro-inflammatory response has been identified as a target in understanding the causes of headache after SAH. A better understanding of this mechanism may lead to identification of molecular targets for therapeutic reduction of headache pain and improving outcomes after SAH. In this study, we collected cerebrospinal fluid (CSF) from patients hospitalized with SAH and conducted a cytokine array to screen for soluble factors involved in SAH-associated headache Introduction

Publication Date

4-25-2022

Publisher

MaineHealth

City

Portland, Maine

Disciplines

Medical Education

Comments

2022 Lambrew Retreat

Recommended Citation

Glisic, Elizabeth; deKay, Joanne T.; Lerwick, Patricia; Gagnon, David J.; Riker, Richard; and Ryzhov, Sergey, "Cytokine CXCL2 concentration in the cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage is associated with patient-reported headache pain" (2022). Costas T. Lambrew Research Retreat 2022. 26.
https://knowledgeconnection.mainehealth.org/lambrew-retreat-2022/26