Low Grade Inflammation and Subtle Metabolic Changes Detected in Long COVID

Authors

• SJ Sahagun, MaineHealth
• Kathryn Stevens, MaineHealthFollow
• Joanne dekay, Maine Medical CenterFollow
• Sergey Ryzhov, MaineHealth Institute for Research, Scarborough, Maine USA.Follow
• Lindsey Gower, MaineHealthFollow
• Shinya U. Amano, MaineHealthFollow
• Benjamin Langer, MaineHealthFollow
• Ivette Emery, MaineHealthFollow
• Clifford J. Rosen, MaineHealth Institute for Research, Scarborough, ME.Follow

Files

Description

• Long Covid is characterized by persistent symptoms lasting 3+ months after initial SARS-CoV-2 viral infection.

• Over 200 symptoms are associated with Long COVID; the most common complaints include: fatigue, brain fog, shortness of breath, and post-exertional malaise.

• To date, there is no definitive understanding of its pathophysiology, which is needed to guide therapy development.

• The PROMIS (Pathobiology in RECOVER Of Metabolic and Immune Systems) study sought to better understand the role of chronic metabolic inflammation, insulin resistance, and T cell dysfunction in patients with Long COVID when compared to control patients with previous COVID-19 infection but without Long COVID symptoms.

Publication Date

4-30-2026

Comments

Presented at the 2026 Costas T. Lambrew Research Retreat

Recommended Citation

Sahagun, SJ; Stevens, Kathryn; dekay, Joanne; Ryzhov, Sergey; Gower, Lindsey; Amano, Shinya U.; Langer, Benjamin; Emery, Ivette; and Rosen, Clifford J., "Low Grade Inflammation and Subtle Metabolic Changes Detected in Long COVID" (2026). Costas T. Lambrew Research Retreat 2026. 8.
https://knowledgeconnection.mainehealth.org/lambrew-retreat-2026/8