Psychotropic medications in children with autism spectrum disorders: a systematic review and synthesis for evidence-based practice.
Maine Behavioral Health
Journal of autism and developmental disorders
Child, Child Development Disorders, Pervasive, Evidence-Based Practice, Humans, Psychotropic Drugs, Treatment Outcome
This paper presents a systematic review, rating and synthesis of the empirical evidence for the use of psychotropic medications in children with autism spectrum disorders (ASD). Thirty-three randomized controlled trials (RCTs) published in peer-reviewed journals qualified for inclusion and were coded and analyzed using a systematic evaluative method specific to autism research (Reichow et al. in Journal of Autism and Developmental Disorders 38:1311-1319, 2008). Results are presented by agent and primary target symptom(s). The findings suggest established evidence for relatively few agents, with preliminary and promising evidence for a larger group. Challenges and opportunities in the developing field of ASD psychopharmacology are identified, and recommendations for further research are provided.
Siegel, Matthew and Beaulieu, Amy A, "Psychotropic medications in children with autism spectrum disorders: a systematic review and synthesis for evidence-based practice." (2012). Maine Medical Center. 1302.