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Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. MaineHealth Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2025

Leveraging strain competition to address antimicrobial resistance with microbiota therapies, Danielle Barrios Steed, Dylan Koundakjian, Anthony D. Harris, Adriana E. Rosato, Konstantinos T. Konstantinidis, and Michael H. Woodworth

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Cardiac Foreign Body, Joshua Rehberg, Alexander Lange, and David C. Mackenzie

"It's hard to talk to a computer, I get it": An exploratory analysis of clinician connection-building communication practices in rural telepalliative care encounters, Elise C. Tarbi

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Efficacy of stochastic vibro-tactile stimulation for newborns at risk of neonatal opioid withdrawal syndrome, Rachana Singh, Ludovic Trinquart, Benjamin Koethe, Mario Cordova, Lawrence Rhein, Shawana Bibi, Jamie Fey, Ariana Anderson, and Jonathan M. Davis

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Ethical Management of Challenging Behaviors in Hospitalized People Who Use Drugs, Christina Yen, Kinna Thakarar, and Tim Lahey

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Perioperative management of patients taking glucagon-like peptide 1 receptor agonists: Society for Perioperative Assessment and Quality Improvement (SPAQI) multidisciplinary consensus statement, Adriana D. Oprea, Laura J. Ostapenko, BobbieJean Sweitzer, Angela Selzer, Joan M. Irizarry-Alvarado, Maria D. Hurtado Andrade, Carlos E. Mendez, Kristen D. Kelley, Erin Stewart, Claudia R. Fernandez Robles, Ryan M. Chadha, Michael Camilleri, Ruchi Mathur, and Guillermo E. Umpierrez

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Safety and efficacy of pegtibatinase enzyme replacement therapy in adults with classical homocystinuria in the COMPOSE® phase 1/2 randomized trial, Can Ficicioglu, Janet A. Thomas, Jaya Ganesh, David Kudrow, Melissa Lah, Wendy E. Smith, Jalé Güner, Sharon McDermott, Sagar A. Vaidya, Liz Wilkening, and Harvey L. Levy

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Early-life and concurrent predictors of the healthy adolescent microbiome in a cohort study, Hannah E. Laue, Amy D. Willis, Fang Wang, Melinda C. MacDougall, Yingying Xu, Margaret R. Karagas, Juliette C. Madan, Abby F. Fleisch, and Bruce P. Lanphear

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Early-life and concurrent predictors of the healthy adolescent microbiome in a cohort study, Hannah E. Laue, Amy D. Willis, Fang Wang, Melinda C. MacDougall, Yingying Xu, Margaret R. Karagas, Juliette C. Madan, Abby F. Fleisch, Bruce P. Lanphear, Kim M. Cecil, Kimberly Yolton, Aimin Chen, Jessie P. Buckley, and Joseph M. Braun

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Arsenic exposure is associated with elevated sweat chloride concentration and airflow obstruction among adults in Bangladesh: A cross-sectional study, Mi-Sun S. Lee, Crystal M. North, Irada Choudhuri, Subrata K. Biswas, Abby F. Fleisch, Afifah Farooque, Diane Bao, Sakila Afroz, Sadia Mow, Nazmul Husain, Fuadul Islam, Md Golam Mostofa, Partha Pratim Biswas, and David S. Ludwig

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Arsenic exposure is associated with elevated sweat chloride concentration and airflow obstruction among adults in Bangladesh: A cross-sectional study, Mi-Sun S. Lee, Crystal M. North, Irada Choudhuri, Subrata K. Biswas, Abby F. Fleisch, Afifah Farooque, Diane Bao, Sakila Afroz, Sadia Mow, Nazmul Husain, Fuadul Islam, Md Golam Mostofa, Partha Pratim Biswas, and David S. Ludwig

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Periprosthetic Joint Infection Centers of Excellence: Moonshot or Misstep? A Survey of the American Association of Hip and Knee Surgeons Members, Meghan Whitmarsh-Brown, Catherine M. Call, Joshua A. Kerr, Carl L. Herndon, Christopher F. Deans, Ameer Elbuluk, Ramakanth Yakkanti, and Adam Rana

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Periprosthetic Joint Infection Centers of Excellence: Moonshot or Misstep? A Survey of the American Association of Hip and Knee Surgeons Members, Meghan Whitmarsh-Brown, Catherine M. Call, Joshua A. Kerr, Carl L. Herndon, Christopher F. Deans, Ameer Elbuluk, Ramakanth Yakkanti, and Adam J. Rana

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Addressing Inpatient Hyponatremia Through Targeted Automatic E-consults: A Pilot Randomized Trial, Timothy J. Judson, Lowell Lo, John E. Demko, Michelle Mourad, Kathleen D. Liu, Robert M. Wachter, Isaac Lopez, and Sri Lekha Tummalapalli

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Addressing Inpatient Hyponatremia Through Targeted Automatic E-consults: A Pilot Randomized Trial, Timothy J. Judson, Lowell Lo, John E. Demko, Michelle Mourad, Kathleen D. Liu, Robert M. Wachter, Isaac Lopez, and Sri Lekha Tummalapalli

Complementary effects of postoperative delirium and frailty on 30-day outcomes in spine surgery, Nithin K. Gupta, Stefan T. Prvulovic, Sina Zoghi, Hikmat R. Chmait, Michael M. Covell, and Cameron J. Sabet

Establishment of an Accurate and Precise Alternative Intraoperative Technique for Determination of Femoral Version, Benjamin Yao, Don Li, Jonathan Cui, Kira L. Smith, Vineet Tyagi, and Joseph B. Kahan

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Ethical considerations in shoulder arthroplasty in patients who are obese, Andrew D. Lachance, Roman Steika, Frank Chessa, Jeffrey Lutton, and Joseph Y. Choi

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Integration of Interprofessional Education Into Routine Resident Practice: 2 Cases of Successful Implementation, Catherine C. Skae, Victoria Gorski, Anna Flattau, Manaslu Gurung, Kalli Varaklis, and Sarah Hallen

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Program Evaluation for Graduate Medical Education: Practical Approaches From the Reimagining Residency Evaluation Community of Practice, Judee Richardson, Lalena M. Yarris, Patricia A. Carney, Erin Goss, Melissa I. Zelaya, Helen K. Morgan, Fei Chen, Julie A. Schumacher, Paul O'Rourke, Colleen Gillespie, Britta M. Thompson, and Mary Ellen Goldhamer

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Seven Tips for Successfully Operationalizing GME Innovations at the System Level: The iPACE Experience, Kalli Varaklis and Sarah Hallen

The Power of Words in Research Reading and Writing, Barbara J. Patterson and Karen H. Morin

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Visuomotor Integration Assessment Using Immersive Virtual Reality for Children With Cerebral Palsy: A Pilot Study, Minxin Cheng, Alexa Craig, and Danielle E. Levac

A Staphylococcus aureus Virulence Inhibitor Identified by SaeRS Refactoring and Screening in Bacillus subtilis, Felix Ekness, Eric A. Wold, Catherine S. Leasure, Elena Musteata, Andrew J. Monteith, and Clare Laut

A Staphylococcus aureus Virulence Inhibitor Identified by SaeRS Refactoring and Screening in Bacillus subtilis, Felix Ekness, Eric A. Wold, Catherine S. Leasure, Elena Musteata, Andrew J. Monteith, and Clare Laut

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The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Pharmacokinetics and Toxicokinetics: Is a New Diagnostic and Therapeutic Framework Needed?, James D. Whitledge, Joseph Kennedy, C James Watson, Carin Malley, Karen Simone, and Mark Neavyn

Coaching Learners During Medical School Training: Faculty Reflections on the Coaching Experience, Maria A. Blanco, Lauren Boehm, and Victoria Hayes

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Establishment of an Accurate and Precise Alternative Intraoperative Technique for Determination of Femoral Version, Benjamin Yao, Don Li, Jonathan Cui, Kira L. Smith, Vineet Tyagi, and Joseph B. Kahan

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Online and in Crisis: When Social Media Impacts Mental Health, Erin L. Belfort and Paul E. Weigle

Predictive Value of Platelet FcγRIIa in Patients Treated With PCI Compared With Medical Therapy Alone After Myocardial Infarction, David J. Schneider, Sean R. McMahon, Dominick J. Angiolillo, Alexander C. Fanaroff, Homam Ibrahim, and Patrick K. Hohl

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Predictive Value of Platelet FcγRIIa in Patients Treated With PCI Compared With Medical Therapy Alone After Myocardial Infarction, David J. Schneider, Sean R. McMahon, Dominick J. Angiolillo, Alexander C. Fanaroff, Homam Ibrahim, and Patrick K. Hohl

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Real-world data of immune-related adverse events in lung cancer patients receiving immune-checkpoint inhibitors, Xiao Hu, Angie Mae Rodday, Anastasia Gurinovich, Stacey Pan, Yana V. Salei, and Jeffrey H. Lin

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Social Media and Development of Sexual and Gender Identity in Adolescents, Daniel J. Suto, Jack L. Turban, and Erin L. Belfort

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The Impact of Social Media Use on the Development of Eating Disorders, Roslyn L. Gerwin and Sahar Ashraf

Worsening Renal Function Is Common and Associated With Higher Mortality in Cardiogenic Shock: A Cardiogenic Shock Working Group Report, Rachna Kataria, Shashank S. Sinha, Song Li, Qiuyue Kong, Manreet Kanwar, and Jaime Hernandez-Montfort

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Adult Patient Perceptions of Nurse Listening Behaviors in an Ambulatory Surgery Setting, Kelly E. Lancaster, Jacqueline Bourque, and Kristiina Hyrkas

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Total Ankle Arthroplasty in Obese Patients: An Ethical Analysis, Andrew D. Lachance, Roman Steika, Frank Chessa, Mohammad T. Azam, Jeffrey Lutton, and Wonyong Lee

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The role of social relationships in recovery court programs, Emma Katherine Dudley, Barbara Andraka-Christou, Alexandra Boland, Danielle N. Atkins, and Ekaterina Pivovarova

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The feasibility and utility of intraoperative ultrasound in spinal cord injury patients: an international survey of AO spine members, Chris J. Neal, Olesja Hazenbiller, Christoph P. Hofstetter, Bizhan Aarabi, James S. Harrop, and Michael G. Fehlings

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Trends Before and After the Removal of Race and Ethnicity from the Vaginal Birth After Cesarean Calculator, Annika Hikade, Kelly Nichols, and Katherine Ahrens

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Update on Psychiatry Residency Training in Personality Disorders: Becoming a Good Psychiatrist Through Becoming "Good Enough" at Treating Borderline and Narcissistic Personality Disorders, G Price Daniel, M Quayle William, and T Unruh Brandon

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AAPM Medical Physics Practice Guideline MPPG 17.a: Quality management for mammography review workstation displays, Rebecca Milman, Nicholas B. Bevins, Mosa Alhamami, Nathan Busse, and Andreea Dohatcu

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Equity in epidemic response: an action-oriented framework for guiding public health in equitable responses to major infectious disease emergencies, Precious-Junia de-Winton Cummings, Kelly K. Baker, Leah Appell, Marina Del Rios, and Daniel Diekema

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The $1,200 Total Joint Arthroplasty Reimbursement: How Did We Get Here, What is the Impact, and What Comes Next?, Catherine M. Call, David DeMik, Ameer Elbuluk, Brian P. Chalmers, Carl L. Herndon, and Adam Rana

A pilot survey into the landscape of neuro-oncology care in the community, Christine Lu-Emerson, Sajeel Chowdhary, Rupesh Kotecha, Akanksha Sharma, Yazmin Odia, and Brian Vaillant

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Evolution of temporomandibular joint reconstruction: from autologous tissue transplantation to alloplastic joint replacement, Hanghang Liu, Liwei Huang, Shibo Liu, Linyi Liu, and Bolun Li

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A Pilot Randomized Control Trial of Holding During Hypothermia and Effects on Maternal and Infant Salivary Cortisol Levels, Leah Fox, Anya K. Cutler, Tomeko Kaneko-Tarui, Kyle Deerwester, Scott Evans, Jill Maron, and Anya K. Cutler

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Training and Assessment of Nontechnical Skills in Cardiothoracic Surgery: Current Literature Review, Chinedu C. Okoli, Obieze C. Nwanna-Nzewunwa, and Scott Buchanan

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Adapting and implementing a pre-hospital trauma program for community health responders: A pilot study from rural Nepal, Ramu Kharel, Mandeep Pathak, Derek Lubetkin, Timmy Lin, and Roshan Paudel

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Telehealth for the study of palliative care communication: opportunities, methodological challenges, and recommendations, Elise C. Tarbi, Susanna L. Schuler, Natalie Ambrose, Rebecca N. Hutchinson, and Maija Reblin

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A Hot Topic: Standardization of Fire Safety Training in Perioperative Areas, Megan Benner MSN-Ed, RN, CPAN, NPD-BC

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Associations of maternal per- and polyfluoroalkyl substance plasma concentrations during pregnancy with offspring polycystic ovary syndrome and related characteristics in project viva, Zifan Wang, Abby Fleisch, Sheryl L. Rifas-Shiman, Antonia M. Calafat, Tamarra James-Todd, and Brent A. Coull

Implementing an Educational Model for Cardiac Arrest Patients During Interfacility Transfers, Michael J. Burla, Drew R. York, Jeanne S. Wishengrad, Peter C. Michalakes, Holly A. Stevens, and Teresa L. May

Severe Left Ventricular Outflow Obstruction by Native Anterior Mitral Leaflet After Bileaflet Preserving Mechanical Mitral Valve Replacement, Obieze Nwanna-Nzewunwa, Chinedu Okoli, Michael E. Jessen, and Suresh Keshavamurthy

The Bibliometric Evolution of Neurosurgery Publications From 1977 to 2023, Michael M. Covell

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Low-volume Resuscitation with VS-101, a Next-Generation PEGylated HBOC, Improves Survival after Severe Hemorrhagic Shock in Rats, William H. Nugent, Kim D. Vandegriff, Ashok Malavalli, Forest R. Sheppard, and Bjorn K. Song

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Testing ChatGPT's Ability to Provide Patient and Physician Information on Aortic Aneurysm, Daniel J. Bertges, Adam W. Beck, Marc Schermerhorn, Mark K. Eskandari, Jens Eldrup-Jorgensen, Sean Liebscher, Robyn Guinto, and Mead Ferris

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Cardiothoracic Surgical Trials Network Update, J Hunter Mehaffey, Raymond Strobel, Benjamin Kramer, Patrick T. O'Gara, Michael J. Mack, Nirav C. Patel, Brittany A. Zwischenberger, and Robert S. Kramer

Conversion from Minimally Invasive Surgical Approaches to Open Surgery Among Patients with Endometrial Cancer in the SGO Clinical Outcomes Registry, Abdelrahman Yousif

Correction: Spatial and temporal distribution of Ixodes scapularis and tick-borne pathogens across the northeastern United States, Lucas E. Price

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Financial impacts of the COVID-19 pandemic on immigrant communities in Portland Maine: a qualitative study, Eilish W. Carpenter

Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact, Enrique Mondragon-Estrada

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CTHRC1 Expression Results in Secretion-Mediated, SOX9-Dependent Suppression of Adipogenesis: Implications for the Regulatory Role of Newly Identified CTHRC1/PDGFR-Alpha Stromal Cells of Adipose, Matthew E. Siviski, Rachel Bercovitch, Kathleen Pyburn, Christian Potts, and Shivangi R. Pande

Telemedicine consultations in community hospitals improve neonatal encephalopathy assessment, Anya Cutler

Perfluoroalkyl substances and preterm birth, Anne M. Mullin

Trends in Orthopaedic Surgeon Compensation: A Comparative Analysis over Twenty Years, Daniel E. Pereira

Prior Authorization in Joint Arthroplasty Surgery: Navigating Challenges, Ramakanth Yakkanti

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Rapid Blood Culture Diagnostics for Ambulatory Management of Uncomplicated Gram-Negative Bloodstream Infections, Martina Boda, Kristina E. Rokas, Christina F. Yen, Daniel J. Diekema, and Nicholas J. Mercuro

A Quality Improvement Initiative to Optimize Follow-Up in the New England Area for Pediatric Patients With Cardiovascular Implantable Electronic Devices, Zoe Schefter

Canagliflozin-induced adaptive metabolism in bone, Sher Bahadur Poudel

Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence, Luigi di Filippo

A "Most Interesting Journey" to America for the International Society of Surgery in 1914, David E. Clark

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Vitamin A deficiency and male-specific effects on heart function in mice, Ian M. Gans, Elena Chepurko, Vadim Chepurko, Grazina A. Mangoba, Mary Ann Asson-Batres, and Calvin P. Vary

Aging alters the effect of adiponectin receptor signaling on bone marrow-derived mesenchymal stem cells, Hanghang Liu

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Buprenorphine in the Intensive Care Unit: Commentary on the Unanswered Questions, David J. Gagnon, Melody J. Glenn, Aurora A. Quaye, and Brian L. Erstad

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Female patients have fewer limb amputations compared to male patients in the BEST-CLI trial, Katharine L. McGinigle, Gheorghe Doros, Olamide Alabi, Benjamin S. Brooke, Ageliki Vouyouka, Jade Hiramoto, and Kristina Giles

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Innovative Technology to Improve Simulation Access for Rural Clinicians, Allison Zanno, Jeffrey Holmes, Misty Melendi, and Michael Ferguson

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Preparing Residents for Rural Practice and Advocacy: The Experiences of Three Residency Training Programs in the Northeast United States (2009-2023), Brian Youth, Carol Lynn O'Dea, and Jill Rinehart

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Rural Pediatric Health Care: A Century of Challenges and a Millennium of Opportunities, Mary Ottolini

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Symptom management in isocitrate dehydrogenase mutant glioma, Tobias Walbert, Edward K. Avila, Florien W. Boele, Caroline Hertler, Christine Lu-Emerson, and Pim B. van der Meer

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The Osmolal Gap: A Valuable Test for Identifying Toxic Alcohol-Induced Anion Gap Metabolic Acidosis, James D. Whitledge, Emily Guy, and Christopher James Watson

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Tools for Improving Access to Subspecialty Care Among Rural Children, Genevieve Whiting and James C. Bohnhoff

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Treatment of Pediatric Obesity in Rural Settings: Identifying and Overcoming Barriers to Care, Rushika Conroy, Carrie Gordon, and Valerie M. O'Hara

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Tropheryma whipplei infection presenting as indolent endophthalmitis, Rami Waked, Jeffrey K. Moore, Brandon Winward, Sophia Ham, Howard W. Hoyt, and Leyla Azis

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Midodrine initiation criteria, dose titration, and adverse effects when administered to treat shock: A systematic review and semi-quantitative analysis, Madeleine M. Puissant, Kaitlin J. Armstrong, Richard R. Riker, Samir Haydar, Tania D. Strout, Kathryn E. Smith, David B. Seder, and David J. Gagnon

Comparison of Lysis and Amplification Methodologies for Optimal 16S rRNA Gene Profiling for Human and Mouse Microbiome Studies, Farzaneh Rastegari

Data Collection Variability Across Neonatal Hypoxic-Ischemic Encephalopathy Registries, Eric S. Peeples

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Inhibition of acyl-CoA synthetase long-chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction, Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, and Michelle Karam

Time Until Operation for Elective Endovascular Aortic Aneurysm Repair in Canadian Vascular Centers Using the Canadian Vascular Quality Initiative Registry, Nadia O. Trabelsi

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Cross-titration from risperidone to clozapine utilizing clozapine serum concentrations: A case report, Nicolette Centanni, Kayla Garvey, Elizabeth Mullany, and Stephanie Nichols

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Rural School-Based Health Centers: Meeting Children Where They Are to Improve Asthma Outcomes, James C. Bohnhoff, Abby Fleisch, and Jill S. Halterman

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Noise audit of device selection for peripheral vascular interventions in the Vascular Quality Initiative, William K. Robinson, Peter W. Callas, Jens Eldrup-Jorgensen, and Daniel J. Bertges

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Performance of transesophageal echocardiography probe at temperature monitoring during simulated hypothermia and rewarming, Madeline Larochelle, Margarita Popova, David Mackenzie, Andrew Fried, Peter Croft, and Joshua Rehberg

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Trends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022, Alexander O. Everhart, Juan P. Brito, Bart L. Clarke, Jeph Herrin, Pinar Karaca-Mandic, Kurt A. Kennel, and Clifford J. Rosen

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Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity, Hanghang Liu, Linyi Liu, and Clifford J. Rosen

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AI Diabetic Retinopathy Screening in a Primary Care Setting in Rural Maine, Rachel Heuer, Emma DayBranch, Anastasia Tsomides, Jessica F. DiBiase, Neil Korsen, and Brian Nolan

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How is Telehealth Used to Increase Access to Specialty Palliative Care? A Systematic Review, Rebecca N. Hutchinson, Eric J. Chiu, Shane C. Belin, Michele Klein-Fedyshin, Carolyn R. Impagliazzo, and Lucia Costanza

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Access to Pediatric Asthma Specialty Care: A Survey and Geospatial Analysis Across a Rural State, James C. Bohnhoff, Dana Schwartz, Anya Cutler, and Jill S. Halterman

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Associations between COVID-19 therapies and outcomes in rural and urban America: A multisite, temporal analysis from the Alpha to Omicron SARS-CoV-2 variants, A Jerrod Anzalone, William H. Beasley, Kimberly Murray, William B. Hillegass, Makayla Schissel, Michael T. Vest, Scott A. Chapman, Ronald Horswell, Lucio Miele, H Timothy Bunnell, Susan L. Santangelo, and Clifford J. Rosen

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C-Reactive Protein Changes in Adult and Pediatric People With Cystic Fibrosis During Treatment of Pulmonary Exacerbations, Jonathan B. Zuckerman, Alexandra C. Hinton, Thomas Lahiri, Charlotte C. Teneback, Shijing Jia, and Joel Mermis