Senescent and apoptotic osteocytes and aging: Exercise to the rescue?

Document Type

Article

Publication Date

4-1-2019

Institution/Department

Endocrinology & Diabetes

Journal Title

Bone

MeSH Headings

Osteocytes, Exercise, Cellular Senescence

Abstract

Osteocytes are the most prevalent cell in the skeleton and are the master regulator of bone remodeling. Despite the understanding that osteocytes have a multiyear lifespan, and some factors induce apoptosis in osteocytes, much less is understood about the induction and consequences of osteocyte senescence. Filling these gaps in knowledge will provide novel approaches to slowing age-related bone loss and preventing fragility fractures. The purpose of this review is to examine the roles of senescence and apoptosis in osteocytes in age-related bone loss. Based on evidence that exercise can prevent senescence in skeletal muscle, we provide a novel hypothesis by which exercise can prolong skeletal health.

ISSN

1873-2763

First Page

255

Last Page

258

Link to Full Text

Share

COinS