A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome.
Center for Molecular Medicine, Maine Medical Center Research Institute
Adipocytes, Beige, Cell Differentiation, Cell Line, Forkhead Transcription Factors, Humans, Induced Pluripotent Stem Cells, Interleukin-4, Mesenchymal Stem Cells, Mesoderm, Metabolic Syndrome, Signal Transduction, Splanchnic Circulation, Transforming Growth Factor beta
Molecular- and cellular-based therapies have the potential to reduce obesity-associated disease. In response to cold, beige adipocytes form in subcutaneous white adipose tissue and convert energy stored in metabolic substrates to heat, making them an attractive therapeutic target. We developed a robust method to generate a renewable source of human beige adipocytes from induced pluripotent stem cells (iPSCs). Developmentally, these cells are derived from FOXF1
Su, Su; Guntur, Anyonya R; Nguyen, Daniel C; Fakory, Shameem S; Doucette, Chad C; Leech, Cassandra; Lotana, Humphrey; Kelley, Matthew; Kohli, Jaspreet; Martino, Julieta; Sims-Lucas, Sunder; Liaw, Lucy; Vary, Calvin; Rosen, Clifford J; and Brown, Aaron C, "A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome." (2018). Maine Medical Center. 1575.