Title

In vitro tissue-engineerd adipose constructs for modeling disease.

Document Type

Article

Publication Date

1-1-2019

Institution/Department

Maine Medical Center Research Institute

Journal Title

BMC Biomed Eng

MeSH Headings

Adipose Tissue, Adipocytes

Abstract

Background: Adipose tissue is a vital tissue in mammals that functions to insulate our bodies, regulate our internal thermostat, protect our organs, store energy (and burn energy, in the case of beige and brown fat), and provide endocrine signals to other organs in the body. Tissue engineering of adipose and other soft tissues may prove essential for people who have lost this tissue from trauma or disease.

Main Text: In this review, we discuss the applications of tissue-engineered adipose tissue specifically for disease modeling applications. We provide a basic background to adipose depots and describe three-dimensional (3D)

Conclusions: The approaches to engineering 3D adipose models are diverse in terms of scaffold type (hydrogel-based, silk-based and scaffold-free), species of origin (

ISSN

2524-4426

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