Title

Type 2 diabetes and aging: a not so sweet scenario for bone.

Document Type

Article

Publication Date

11-2016

Institution/Department

MMCRI

Journal Title

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

MeSH Headings

Aging, Diabetes Mellitus, Type 2, Fractures, Bone, Humans, Hypoglycemic Agents, Risk Factors

ISSN

1439-4286

Abstract

Type 2 diabetes and fractures are associated with substantial mortality and morbidity in the aging population. Given the normal to high bone mineral density, skeletal fragility in type 2 diabetes is an intriguing topic of ongoing research. An improved understanding of the underlying mechanisms and regulators of bone pathology in diabetes is needed to formulate targeted prevention and intervention strategies in this high risk population. Although the changes in bone induced by aging and disease are divergent, the pathogenetic mechanisms of aging and type 2 diabetes, thus far known, are not mutually exclusive. These mechanisms may provide deeper insight into the quantitative and qualitative deficits to further our knowledge of diabetes-specific bone pathology.

Comments

Center for Clinical & Translational Research, Scarborough, ME.

First Page

771

Last Page

778

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