Impact of Initial Shunt Type on Echocardiographic Indices in Children After Single Right Ventricle Palliations.
Circ Cardiovasc Imaging
Blalock-Taussig Procedure, Child, Child, Preschool, Echocardiography, Doppler, Female, Heart Defects, Congenital, Heart Ventricles, Humans, Male, Norwood Procedures, Palliative Care, Predictive Value of Tests, Recovery of Function, Time Factors, Treatment Outcome, Ventricular Function, Right, Ventricular Remodeling
Background Heart size and function in children with single right ventricle (RV) anomalies may be influenced by shunt type at the Norwood procedure. We sought to identify shunt-related differences during early childhood after staged surgical palliations using echocardiography. Methods We compared echocardiographic indices of RV, neoaortic, and tricuspid valve size and function at 14 months, pre-Fontan, and 6 years in 241 subjects randomized to a Norwood procedure using either the modified Blalock-Taussig shunt or RV-to-pulmonary-artery shunt. Results At 6 years, the shunt groups did not differ significantly in any measure except for increased indexed neoaortic area in the modified Blalock-Taussig shunt. RV ejection fraction improved between pre-Fontan and 6 years in the RV-to-pulmonary artery shunt group but was stable in the modified Blalock-Taussig shunt group. For the entire cohort, RV diastolic and systolic size and functional indices were improved at 6 years compared with earlier measurements, and indexed tricuspid and neoaortic annular area decreased from 14 months to 6 years. The prevalence of ≥moderate tricuspid and neoaortic regurgitation was uncommon and did not vary by group or time period. Diminished RV ejection fraction at the 14-month study was predictive of late death/transplant; the hazard of late death/transplant when RV ejection fraction was
Frommelt, Peter C; Hu, Chenwei; Trachtenberg, Felicia; Baffa, Jeanne Marie; Boruta, Richard J; Chowdhury, Shahryar; Cnota, James F; Dragulescu, Andreea; Levine, Jami C; Lu, Jimmy; Mercer-Rosa, Laura; Miller, Thomas; Shah, Amee; Slesnick, Timothy C; Stapleton, Gary; Stelter, Jessica; Wong, Pierre; and Newburger, Jane W, "Impact of Initial Shunt Type on Echocardiographic Indices in Children After Single Right Ventricle Palliations." (2019). Maine Medical Center. 1852.