Title

Tissue-engineered 3D cancer-in-bone modeling: silk and PUR protocols.

Document Type

Article

Publication Date

1-2016

Institution/Department

MMCRI

Journal Title

BoneKEy reports

ISSN

2047-6396

Abstract

Cancers that metastasize or grow in the bone marrow are typically considered incurable and cause extensive damage to the bone and bone marrow. The bone is a complex, dynamic, three-dimensional (3D) environment composed of a plethora of cells that may contribute to, or constrain, the growth of tumor cells and development of bone disease. The development of safe and effective drugs is currently hampered by pre-clinical two-dimensional (2D) models whose poor predictive power does not accurately predict the success or failure of therapeutics. These inadequate models often result in drugs proceeding through extensive pre-clinical studies only to fail clinically. Consistently, 3D co-culture systems prove superior to 2D mono-cultures in modeling

First Page

842

Last Page

842

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