Common Mechanistic Pathways in Cancer and Heart Failure.
Center for Molecular Medicine, Maine Medical Center Research Institute
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology
Heart Failure, Neoplasms
The co-occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. Inflammation emerges as a common hallmark for both diseases as it contributes to the initiation, and progression of both HF and cancer. Under stress, malignant and cardiac cells change their metabolic preferences to survive, which makes these metabolic derangements a great basis to develop intersection strategies and therapies to combat both diseases. Further, genetic predisposition and clonal hematopoiesis are common drivers for both conditions and they hold great clinical relevance in the context of personalized medicine. Also, altered angiogenesis is a common hallmark for failing hearts and tumors and represents a promising substrate to target in both diseases. Cardiac cells and malignant cells interact with their surrounding environment called stroma. This interaction mediates the progression of the 2 pathologies and understanding the structure and function of each stromal component may pave the way for innovative therapeutic strategies and improved outcomes in patients. The interdisciplinary collaboration between cardiologists and oncologists is essential to establish unified guidelines. Also, preclinical models that mimic the human situation, where both pathologies coexist, are needed to understand all the aspects of the bidirectional relationship between cancer and HF. Finally, adequately powered clinical studies, including all ages, and men and women, with proper adjudication of both cancer and CV end points, are essential to accurately study these two pathologies at the same time.
de Boer, Rudolf A; Hulot, Jean-Sébastien; Gabriele Tocchetti, Carlo; Aboumsallem, Joseph Pierre; Ameri, Pietro; Anker, Stefan D; Bauersachs, Johann; Bertero, Edoardo; Coats, Andrew A J; Čelutkienė, Jelena; Chioncel, Ovidiu; Dodion, Pierre; Eschenhagen, Thomas; Farmakis, Dimitrios; Bayes-Genis, Antoni; Jäger, Dirk; Jankowska, Ewa A; Kitsis, Richard N; Konety, Suma H; Larkin, James; Lehmann, Lorenz; Lenihan, Daniel J; Maack, Christoph; Moslehi, Javid; Müller, Oliver J; Nowak-Sliwinska, Patrycja; Piepoli, Massimo Francesco; Ponikowski, Piotr; Pudil, Radek; Rainer, Peter P; Ruschitzka, Frank; Sawyer, Douglas; Seferovic, Petar M; Suter, Thomas; Thum, Thomas; van der Meer, Peter; Van Laake, Linda W; von Haehling, Stephan; Heymans, Stephane; Lyon, Alexander R; and Backs, Johannes, "Common Mechanistic Pathways in Cancer and Heart Failure." (2020). Maine Medical Center. 1957.