Early increases in concentrations of total, LDL, and HDL cholesterol in HIV-infected children following new exposure to antiretroviral therapy.

Document Type

Article

Publication Date

4-1-2011

Institution/Department

Pediatrics

Journal Title

Journal of pediatric gastroenterology and nutrition

MeSH Headings

Adolescent, Anti-Retroviral Agents, Cardiovascular Diseases, Child, Child, Preschool, Cholesterol, Cholesterol, HDL, Cholesterol, LDL, Dyslipidemias, Female, HIV Infections, Humans, Infant, Infant, Newborn, Male, Risk Factors, Time Factors

Abstract

Antiretroviral therapy (ART) is associated with dyslipidemia and cardiovascular disease in adults infected with HIV. For children perinatally infected with HIV, ART exposure is lifelong and early-onset dyslipidemia could have significant long-term effects. We examined cholesterol levels in children during the first year after exposure to a new ART regimen (initiation or switch). In 52 children, total cholesterol increased by 30.5 and 43 mg/dL at 6 and 12 months, respectively (P < 0.001). Low-density lipoprotein cholesterol made the largest contribution, but high-density lipoprotein cholesterol also increased within months of therapy alteration. Early identification of these children and intervention could mediate potential increased risk for future cardiovascular disease.

ISSN

1536-4801

First Page

495

Last Page

498

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