First trimester transabdominal chorionic villus sampling--does the needle matter?

Document Type


Publication Date



Obstetrics & Gynecology

Journal Title

Journal of clinical ultrasound : JCU

MeSH Headings

Adult, Chorionic Villi Sampling, Female, Humans, In Situ Hybridization, Fluorescence, Middle Aged, Needles, Outcome Assessment, Health Care, Pregnancy, Pregnancy Trimester, First, Retrospective Studies


PURPOSE: To compare first-trimester transabdominal chorionic villus samples (TA-CVS) when obtained by 20-gauge amniocentesis versus lancet needles.

METHODS: This is a retrospective study of all women with viable singleton pregnancies undergoing TA-CVS from 01/01/2009 to 03/31/2011. All CVS were performed by a single operator using a freehand technique and amniocentesis needles from 01/01/2009 to 08/31/2010 and lancet needles from 09/01/2010 to 03/31/2011. All samples were processed by the same laboratory.

RESULTS: There were no differences between groups regarding maternal age, weight, gestational age at CVS, indication for CVS, uterine position, or placental location. Lancet needles were associated with significantly larger samples (median 18 [range 3-40] versus 7 [range 1-33] mg, p < 0.0001), more successful in situ hybridization (96% versus 74.2%, p = 0.03), and faster result reporting (median 7 [range 5-12] versus 9 [range 6-26] days, p = 0.002).

CONCLUSIONS: Needle type may be clinically important when selecting 20-gauge TA-CVS needles.



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