Bone marrow adipose tissue in metabolic health
Trends in endocrinology and metabolism: TEM
Recent studies have highlighted the role of bone marrow adipose tissue (BMAT) as a regulator of skeletal homeostasis and energy metabolism. While long considered an inert filler, occupying empty spaces from bone loss and reduced hematopoiesis, BMAT is now considered a secretory and metabolic organ that responds to nutritional challenges and secretes cytokines, which indirectly impact energy and bone metabolism. The recent advances in our understanding of the function of BMAT have been enabled by novel noninvasive imaging techniques, which allow longitudinal assessment of BMAT in vivo following interventions. This review will focus on the latest advances in our understanding of BMAT and its role in metabolic health. Imaging techniques to quantify the content and composition of BMAT will be discussed.
Pachón-Peña G, Bredella MA. Bone marrow adipose tissue in metabolic health [published online ahead of print, 2022 Apr 5]. Trends Endocrinol Metab. 2022;S1043-2760(22)00055-8. doi:10.1016/j.tem.2022.03.003