Identified Enrollment Challenges of Adolescent and Young Adult Patients on the Nonchemotherapy Arm of Children's Oncology Group Study ARST1321


Viswatej Avutu, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Aaron R. Weiss, Department of Pediatrics, Maine Medical Center, Portland, Maine, USA.
Damon R. Reed, Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, Florida, USA.
Safia K. Ahmed, Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.Follow
Wendy A. Allen-Rhoades, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Yen-Lin E. Chen, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Lara E. Davis, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Bree R. Eaton, Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.
Douglas S. Hawkins, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA.
Danny J. Indelicato, Department of Radiation Oncology, University of Florida, Jacksonville, Florida, USA.
Shreyaskumar R. Patel, Department of Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
R Lor Randall, Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA.
Denise K. Reinke, Sarcoma Alliance for Research through Collaboration, Ann Arbor, Michigan, USA.
Richard F. Riedel, Department of Medicine, Duke Cancer Institute, Durham, North Carolina, USA.
Thomas J. Scharschmidt, Department of Orthopaedic Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Katherine A. Thornton, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Dian Wang, Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois, USA.
Katherine A. Janeway, Department of Pediatrics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Lisa M. Kopp, Department of Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona, USA.

Document Type


Publication Date



Pediatrics, Oncology

Journal Title

Journal of adolescent and young adult oncology

MeSH Headings

Adolescent; Adult; Clinical Trials as Topic; Humans; Patient Participation; Sarcoma (pathology, therapy); Soft Tissue Neoplasms (pathology, therapy); Surveys and Questionnaires; Young Adult


ARST1321, a trial of patients with advanced soft tissue sarcoma, was the first National Clinical Trials Network study codeveloped by pediatric and adult consortia with two treatment cohorts. We report on the findings of a survey to identify barriers to enrolling adolescent and young adult patients (15-39 years) onto the nonchemotherapy arm. The survey response rate was 31% with a 70% completion rate. Common identified reasons for low accrual in order of decreasing frequency included insufficient funding, lack of study awareness or interest, competing trials, toxicity concerns, philosophical differences in the therapy backbone, and regulatory and infrastructure barriers. Clinical Trials.gov ID: NCT02180867.

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