A Pilot Study of Cyclosporine for the Prevention of Postsurgical Adhesion Formation In Rats

Document Type

Article

Publication Date

5-1995

Institution/Department

Obstetrics and Gynecology

Journal Title

American Journal of Obstetrics and Gynecology

MeSH Headings

Animals; Cyclosporine (therapeutic use); Female; Pilot Projects; Postoperative Complications (prevention & control); Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Adhesions (prevention & control); Uterine Diseases (prevention & control)

Abstract

OBJECTIVE: Our purpose was to evaluate the efficacy of cyclosporine in preventing primary postsurgical adhesions in the rat model. STUDY DESIGN: Thirty-two Sprague-Dawley rats underwent unilateral uterine horn injury with a combination of unipolar and bipolar cautery. Sixteen of the rats were randomized to the treatment group and received preoperative and daily cyclosporine dosing (10 mg/kg) by gavage for 14 days. At the end of the study all animals were killed, and a standard adhesion scoring system was applied by a blinded examiner. RESULTS: Adhesions were present in 75% of rats in both groups. Treatment did not affect the total adhesion score. CONCLUSION: Cyclosporine does not appear promising as a means to decrease postsurgical adhesion formation.

ISSN

0002-9378

First Page

1537

Last Page

9

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