A Pilot Study of Cyclosporine for the Prevention of Postsurgical Adhesion Formation In Rats
Obstetrics and Gynecology
American Journal of Obstetrics and Gynecology
Animals; Cyclosporine (therapeutic use); Female; Pilot Projects; Postoperative Complications (prevention & control); Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Adhesions (prevention & control); Uterine Diseases (prevention & control)
OBJECTIVE: Our purpose was to evaluate the efficacy of cyclosporine in preventing primary postsurgical adhesions in the rat model. STUDY DESIGN: Thirty-two Sprague-Dawley rats underwent unilateral uterine horn injury with a combination of unipolar and bipolar cautery. Sixteen of the rats were randomized to the treatment group and received preoperative and daily cyclosporine dosing (10 mg/kg) by gavage for 14 days. At the end of the study all animals were killed, and a standard adhesion scoring system was applied by a blinded examiner. RESULTS: Adhesions were present in 75% of rats in both groups. Treatment did not affect the total adhesion score. CONCLUSION: Cyclosporine does not appear promising as a means to decrease postsurgical adhesion formation.
Leondires MP, Stubblefield PG, Tarraza HM, Jones MA. A pilot study of cyclosporine for the prevention of postsurgical adhesion formation in rats. Am J Obstet Gynecol. 1995;172(5):1537-1539. doi:10.1016/0002-9378(95)90492-1