Title

The bone-fat interface: basic and clinical implications of marrow adiposity.

Document Type

Article

Publication Date

2-1-2015

Institution/Department

MMCRI

Journal Title

Lancet diabetes and endocrinology

MeSH Headings

Adipocytes, Adipose Tissue, Animals, Anorexia Nervosa, Bone Marrow, Diabetes Mellitus, Female, Humans, Male, Mice, Obesity, Osteoporosis, Rats

ISSN

2213-8595

Abstract

Obesity and osteoporosis are two of the most common chronic disorders of the 21st century. Both are accompanied by significant morbidity. The only place in the mammalian organism where bone and fat lie adjacent to each other is in the bone marrow. Marrow adipose tissue is a dynamic depot that probably exists as both constitutive and regulated compartments. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. The relationship of marrow adipose tissue to other fat depots is complex and might play very distinct parts in modulation of metabolic homoeostasis, haemopoiesis, and osteogenesis. Understanding of the relationship between bone and fat cells that arise from the same progenitor within the bone marrow niche provides insight into the pathophysiology of age-related osteoporosis, diabetes, and obesity.

First Page

141

Last Page

147

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