Title

Nonvitamin K anticoagulant agents in patients with advanced chronic kidney disease or on dialysis with AF.

Document Type

Article

Publication Date

6-21-2016

Institution/Department

Nephrology

Journal Title

Journal of the American College of Cardiology

MeSH Headings

Anticoagulants, Atrial Fibrillation, Creatinine, Dabigatran, Glomerular Filtration Rate, Hemorrhage, Humans, Kidney, Kidney Failure, Chronic, Pyrazoles, Pyridines, Pyridones, Renal Dialysis, Renal Insufficiency, Chronic, Rivaroxaban, Stroke, Thiazoles, Warfarin

ISSN

1558-3597

Abstract

Nonvitamin K-dependent oral anticoagulant agents (NOACs) are currently recommended for patients with atrial fibrillation at risk for stroke. As a group, NOACs significantly reduce stroke, intracranial hemorrhage, and mortality, with lower to similar major bleeding rates compared with warfarin. All NOACs are dependent on the kidney for elimination, such that patients with creatinine clearance/min were excluded from all the pivotal phase 3 NOAC trials. It therefore remains unclear how or if NOACs should be prescribed to patients with advanced chronic kidney disease and those on dialysis. The authors review the current pharmacokinetic, observational, and prospective data on NOACs in patients with advanced chronic kidney disease (creatinine clearance/min) and those on dialysis. The authors frame the evidence in terms of risk versus benefit to bring greater clarity to NOAC-related major bleeding and efficacy at preventing stroke specifically in patients with creatinine clearance/min.

First Page

2888

Last Page

2899

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