CTHRC1 and Immune Cell Interactions

Barbara Toomey, MaineHealth
Ville Vikki
Haylee Duval
Christian Potts, MaineHealth
Edward Jachimowicz, MaineHealth
Sergey Ryzhov, MaineHealth
Volkhard Lindner, MaineHealth

Presented at the 2026 Costas T. Lambrew Research Retreat

Abstract

Introduction: CTHRC1 Induces T Cell Proliferation Future Directions Conclusions Methods CTHRC1 Binds Immune Cells RNA Sequencing Identifies Macrophages Collagen triple helix repeat containing 1 (CTHRC1) is a secreted protein with a role in cellular metabolism that is expressed during tissue repair and remodeling and during pathological conditions including cancer and fibrosis.