Governing roles for Trib3 pseudokinase during stress erythropoiesis.

Document Type

Article

Publication Date

5-1-2017

Institution/Department

Molecular Medicine, MMCRI

Journal Title

Experimental hematology.

MeSH Headings

Animals, Bone Marrow, Cell Cycle Proteins, Erythrocytes, Erythroid Precursor Cells, Erythropoiesis, Erythropoietin, Fluorouracil, Gene Expression Regulation, Mice, Mice, Knockout, Mitogen-Activated Protein Kinase 3, Stress, Physiological

Abstract

In response to anemia, the heightened production of erythropoietin (EPO) can sharply promote erythroid progenitor cell (EPC) formation. Specific mediators of such EPO- accelerated erythropoiesis, however, are not well understood. Presently, we first report that the expression of Trib3 in adult bone marrow EPCs in vivo is nominal at steady state, but strongly activated on EPO challenge. In a knockout mouse model, Trib3 disruption modestly increased steady-state erythrocyte numbers and decreased mean corpuscular volume. Following 5-fluorouracil myeloablation, however, rebound red blood cell production and hemoglobin levels were substantially (and selectively) compromised in Trib3

ISSN

1873-2399

First Page

48

Last Page

55

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