IGFBP-4 regulates adult skeletal growth in a sex-specific manner.
The Journal of endocrinology.
Animals, Body Weight, Bone Development, Bone and Bones, Female, Insulin-Like Growth Factor Binding Protein 4, Male, Mice, Mice, Knockout, Osteoclasts, Osteogenesis, Sex Characteristics
Insulin-like growth factor-1 (IGF-1) and its binding proteins are critical mediators of skeletal growth. Insulin-like growth factor-binding protein 4 (IGFBP-4) is highly expressed in osteoblasts and inhibits IGF-1 actions
Maridas, David E; DeMambro, Victoria E; Le, Phuong T; Nagano, Kenichi; Baron, Roland; Mohan, Subburaman; and Rosen, Clifford J, "IGFBP-4 regulates adult skeletal growth in a sex-specific manner." (2017). Maine Medical Center. 638.