Title

IGFBP-4 regulates adult skeletal growth in a sex-specific manner.

Document Type

Article

Publication Date

4-1-2017

Institution/Department

MMCRI

Journal Title

The Journal of endocrinology.

MeSH Headings

Animals, Body Weight, Bone Development, Bone and Bones, Female, Insulin-Like Growth Factor Binding Protein 4, Male, Mice, Mice, Knockout, Osteoclasts, Osteogenesis, Sex Characteristics

Abstract

Insulin-like growth factor-1 (IGF-1) and its binding proteins are critical mediators of skeletal growth. Insulin-like growth factor-binding protein 4 (IGFBP-4) is highly expressed in osteoblasts and inhibits IGF-1 actions

ISSN

1479-6805

First Page

131

Last Page

144

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