Anesthesiology & Pain Management, Medical Education, Maine Medical Center Research Institute, Center for Outcomes Research and Evaluation
• Intermediate and long acting opioids are given intraoperatively to reduce pain during emergence from anesthesia.
• Recent evidence suggests that intraoperative opioids have inconsistent effects on nociception and pain in the immediate postoperative period.
• Multiple potent, short-acting opioids such as remifentanil, sufentanil and fentanyl have been shown to produce dose-related increases in pain scores and opioid consumption in the immediate postoperative recovery period.
• Intraoperative doses of longer acting opioids such as morphine and methadone6 have been shown to reduce pain scores and narcotic requirements in the immediate postoperative period.
• Hydromorphone is an intermediate duration narcotic which is commonly used intraoperatively but has not been studied for its potential to reduce pain in the immediate postoperative period.
Curry, Craig S.; Henry, Michael B.; Craig, Wendy C.; Richard, Janelle M.; and Ward, Denham S., "Increasing Doses of Intraoperative Hydromorphone Do Not Reduce Postoperative Pain" (2019). Maine Medical Center. 688.