Treatment of Distal Anterior Circulation Aneurysms With the Pipeline Embolization Device: A US Multicenter Experience.
Neurology and Neuroscience
Aged, Anterior Cerebral Artery, Embolization, Therapeutic, Endovascular Procedures, Equipment Failure, Female, Follow-Up Studies, Humans, Intracranial Aneurysm, Male, Middle Aged, Retrospective Studies, Treatment Outcome, United States
BACKGROUND: Utilization of the Pipeline embolization device (PED) to treat distal carotid circulation aneurysms has not been well studied.
OBJECTIVE: To report the collective experience of using PED to treat distal anterior circulation aneurysms.
METHODS: We retrospectively reviewed clinical and radiographic records of all patients who underwent Pipeline embolization of distal anterior circulation aneurysms at 10 US neurosurgical centers between 2011 and 2013.
RESULTS: Twenty-eight patients (mean age 51.7 years; 18 women) with 28 aneurysms were included in the analyses. Fifteen aneurysms were fusiform, 5 dissecting, and 8 saccular. Average aneurysm size was 12.3 mm; 7 were giant. Twenty aneurysms were located along the middle cerebral artery, 6 along the anterior cerebral artery, and 2 along the anterior communicating artery. PED deployment was successful in 27 patients, with coils utilized in 6 cases. Clinical follow-up was available for an average of 10.7 months (range 3-26). Twenty-seven patients had follow-up neurovascular imaging: 21 aneurysms had complete occlusion, 4 had residual neck filling, and 2 had residual dome filling. Periprocedural complications (<30 >days) occurred in 3 patients (10.7%), including 1 case of device failure resulting in stroke. Outcomes were good (modified Rankin Scale score 0 to 2) in 27 patients (96.4%) and fair (modified Rankin Scale 3) in 1.
CONCLUSION: PED can be utilized in the treatment of distal anterior circulation aneurysms with difficult anatomy for conventional surgical or endovascular techniques. Larger-scale studies with long-term follow-up are needed to further elucidate the durability of PED treatment and its effect on perforator-rich vascular segments.
ABBREVIATIONS: ACA, anterior cerebral arteryAcomA, anterior communicating arteryDSA, digital subtraction angiographyMCA, middle cerebral arterymRS, modified Rankin scalePED, Pipeline embolization device.
Lin, Ning; Lanzino, Giuseppe; Lopes, Demetrius K; Arthur, Adam S; Ogilvy, Christopher S; Ecker, Robert D; Dumont, Travis M; Turner, Raymond D; Gooch, M Reid; Boulos, Alan S; Kan, Peter; Snyder, Kenneth V; Levy, Elad I; and Siddiqui, Adnan H, "Treatment of Distal Anterior Circulation Aneurysms With the Pipeline Embolization Device: A US Multicenter Experience." (2016). Maine Medical Center. 797.