Title

Peripheral brain derived neurotrophic factor (BDNF) in bulimia nervosa: a systematic review.

Document Type

Article

Publication Date

4-1-2014

Institution/Department

Nursing

Journal Title

Archives of psychiatric nursing

MeSH Headings

Animals, Brain-Derived Neurotrophic Factor, Bulimia Nervosa, Humans

ISSN

1532-8228

Abstract

INTRODUCTION: Currently, there is limited understanding of the etiology of BN. While multifaceted etiology is likely, several neurobiological factors may play a role. Brain derived neurotrophic factor (BDNF), a potential biomarker linked to eating and weight disorders, is one factor of recent investigation. This paper examined studies comparing BDNF blood levels in BN to healthy control (HC) subjects.

METHODS: A systematic review of the literature was conducted utilizing five databases (PubMed, CINAHL, EMBASE, PsycINFO, and Medline). Key terms included eating disorders, BDNF, and bulimia nervosa.

CONCLUSIONS: BDNF blood levels appear lower in BN than in HC subjects; however, studies are needed to examine the influence of possible correlates including symptom severity, mood, medications, exercise, and substance use.

First Page

108

Last Page

113

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