Document Type
Patent
Publication Date
11-30-1999
Patent Number
5994078
Abstract
Stable reference nucleic acid for use in all steps of molecular screening and diagnostic assays and method of making. A desired nucleic acid sequence is amplified, ligated into an expression vector, and used to transform a vehicle. A cellular vehicle is subsequently killed without affecting the encapsulated nucleic acid. The vehicle membrane is stabilized under controlled conditions to a stability substantially matching that of a test cell membrane. The recovered nucleic acid is used as a standard or control in molecular diagnostic and genetic testing assays.
Application Number
08997522
Institution/Department
Maine Medical Center
Recommended Citation
Rundell, Clark A. and Vary, Calvin, "Stable Encapsulated Reference Nucleic Acid and Method of Making" (1999). MaineHealth Patents. 2.
https://knowledgeconnection.mainehealth.org/patents/2
Assignees
Maine Medical Center
Filing Date
12/23/1997