Document Type

Patent

Publication Date

11-30-1999

Patent Number

5994078

Abstract

Stable reference nucleic acid for use in all steps of molecular screening and diagnostic assays and method of making. A desired nucleic acid sequence is amplified, ligated into an expression vector, and used to transform a vehicle. A cellular vehicle is subsequently killed without affecting the encapsulated nucleic acid. The vehicle membrane is stabilized under controlled conditions to a stability substantially matching that of a test cell membrane. The recovered nucleic acid is used as a standard or control in molecular diagnostic and genetic testing assays.

Application Number

08997522

Institution/Department

Maine Medical Center

Assignees

Maine Medical Center

Filing Date

12/23/1997

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