ErbB3 signaling prevents cardiac fibrosis after isoproterenol-induced myocardial injury

Authors

Sergey Tsibulnikov, Maine Medical CenterFollow
Laccey Knudsen, Maine Medical CenterFollow
Elena Chepurko, Maine Medical CenterFollow
Vadim Chepurko, Maine Medical CenterFollow
Joanne dekay, Maine Medical CenterFollow
Douglas Sawyer, Maine Medical CenterFollow

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Description

We generate a new tamoxifen-inducible mice model of EC-specific ErbB3 overexpression to investigate the role of ErbB3 in myocardial ischemia and heart failure. In the present study, we compared cardiac function and fibrosis development in EC cell-specific ErbB3 overexpressing mice versus control after the Isoproterenol (ISO)-induced model of cardiac injury, which culminates in cardiac fibrosis development.

Institution/Department

Maine Medical Center, Center for Molecular Medicine

Publication Date

5-2023

Publisher

MaineHealth

City

Portland

Keywords

Molecular Medicine, Cardiac Fibrosis, Myocardial Injury, Medical Research

Recommended Citation

Tsibulnikov, Sergey; Knudsen, Laccey; Chepurko, Elena; Chepurko, Vadim; dekay, Joanne; and Sawyer, Douglas, "ErbB3 signaling prevents cardiac fibrosis after isoproterenol-induced myocardial injury" (2023). Costas T. Lambrew Research Retreat 2023. 14.
https://knowledgeconnection.mainehealth.org/lambrew-retreat-2023/14