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We generate a new tamoxifen-inducible mice model of EC-specific ErbB3 overexpression to investigate the role of ErbB3 in myocardial ischemia and heart failure. In the present study, we compared cardiac function and fibrosis development in EC cell-specific ErbB3 overexpressing mice versus control after the Isoproterenol (ISO)-induced model of cardiac injury, which culminates in cardiac fibrosis development.
Maine Medical Center, Center for Molecular Medicine
Molecular Medicine, Cardiac Fibrosis, Myocardial Injury, Medical Research
Tsibulnikov, Sergey; Knudsen, Laccey; Chepurko, Elena; Chepurko, Vadim; dekay, Joanne; and Sawyer, Douglas, "ErbB3 signaling prevents cardiac fibrosis after isoproterenol-induced myocardial injury" (2023). Costas T. Lambrew Research Retreat 2023. 14.