Bcl-2 expression in pericytes and astrocytes impacts vascular development and homeostasis.
Document Type
Article
Publication Date
7-4-2019
Journal Title
Scientific reports.
Abstract
B-cell lymphoma 2 (Bcl-2) protein is the founding member of a group of proteins known to modulate apoptosis. Its discovery set the stage for identification of family members with either pro- or anti-apoptotic properties. Expression of Bcl-2 plays an important role during angiogenesis by influencing not only vascular cell survival, but also migration and adhesion. Although apoptosis and migration are postulated to have roles during vascular remodeling and regression, the contribution of Bcl-2 continues to emerge. We previously noted that the impaired retinal vascularization and an inability to undergo pathologic neovascularization observed in mice globally lacking Bcl-2 did not occur when mice lacked the expression of Bcl-2 only in endothelial cells. To further examine the effect of Bcl-2 expression during vascularization of the retina, we assessed its contribution in pericytes or astrocytes by generating mice with a conditional Bcl-2 allele (Bcl-2
ISSN
2045-2322
First Page
9700
Last Page
9700
Recommended Citation
Zaitoun, Ismail S; Wintheiser, Catherine M; Jamali, Nasim; Wang, Shoujian; Suscha, Andrew; Darjatmoko, Soesiawati R; Schleck, Katherine; Hanna, Barbara A; Lindner, Volkhard; Sheibani, Nader; and Sorenson, Christine M, "Bcl-2 expression in pericytes and astrocytes impacts vascular development and homeostasis." (2019). MaineHealth Maine Medical Center. 1039.
https://knowledgeconnection.mainehealth.org/mmc/1039