Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr

Document Type

Article

Publication Date

4-1-2018

Institution/Department

Center for Molecular Medicine, Maine Medical Center Research Institute

Journal Title

Annals of the New York Academy of Sciences

MeSH Headings

Animals, Blood Glucose, Body Composition, Body Weight, Cardiomyopathies, Cardiotonic Agents, Diabetes Mellitus, Type 2, Diet, Disease Models, Animal, Echocardiography, Female, Insulin, Insulin Resistance, Longevity, Male, Mice, Mice, Inbred C57BL, Sirolimus, Weight Gain

Abstract

Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardiomyopathy. In view of this, we used a murine model of type 2 diabetes (T2D), BKS-Lepr

ISSN

1749-6632

First Page

106

Last Page

117

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