Marrow Adipocytes: Origin, Structure, and Function.
Document Type
Article
Publication Date
2-10-2020
Institution/Department
Maine Medical Center Research Institute, Center for Clinical & Translational Research
Journal Title
Annual review of physiology
MeSH Headings
Bone Marrow, Adipocytes, Vegetables, Cells
Abstract
The skeleton harbors an array of lineage cells that have an essential role in whole body homeostasis. Adipocytes start the colonization of marrow space early in postnatal life, expanding progressively and influencing other components of the bone marrow through paracrine signaling. In this unique, closed, and hypoxic environment close to the endosteal surface and adjacent to the microvascular space the marrow adipocyte can store or provide energy, secrete adipokines, and target neighboring bone cells. Adipocyte progenitors can also migrate from the bone marrow to populate white adipose tissue, a process that accelerates during weight gain. The marrow adipocyte also has an endocrine role in whole body homeostasis through its varied secretome that targets distant adipose depots, skeletal muscle, and the nervous system. Further insights into the biology of this unique and versatile cell will undoubtedly lead to novel therapeutic approaches to metabolic and age-related disorders such as osteoporosis and diabetes mellitus.
ISSN
1545-1585
First Page
461
Last Page
484
Recommended Citation
de Paula, Francisco J A and Rosen, Clifford J, "Marrow Adipocytes: Origin, Structure, and Function." (2020). Maine Medical Center. 1493.
https://knowledgeconnection.mainehealth.org/mmc/1493
