Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity.
Maine Medical Center Research Institute
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Adipose Tissue, Adiposity, Aged, 80 and over, Bone Marrow, Female, Glomerular Filtration Rate, Humans, Male, Renal Insufficiency, Chronic
Bone marrow adiposity is associated with aging, osteoporosis, and reduced hematopoiesis, as well as anorexia nervosa, but little is known about the underlying mechanisms that affect marrow adiposity. Chronic kidney disease (CKD) may influence bone marrow adipose tissue (BMAT), possibly through loss of lean mass or higher circulating levels of sclerostin. To test these hypotheses, we investigated the cross-sectional association between estimated glomerular filtration rate (eGFR) as a measure of kidney function and
Woods, Gina N; Ewing, Susan K; Sigurdsson, Sigurdur; Kado, Deborah M; Ix, Joachim H; Hue, Trisha F; Eiriksdottir, Gudny; Xu, Kaipin; Gudnason, Vilmundur; Lang, Thomas F; Vittinghoff, Eric; Harris, Tamara B; Rosen, Clifford J; Li, Xiaojuan; and Schwartz, Ann V, "Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity." (2018). Maine Medical Center. 1545.