Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells.

Authors

Michaela Tencerova
Elizabeth Rendina-Ruedy, Maine Medical Center
Ditte Neess
Nils Færgeman
Florence Figeac
Dalia Ali
Morten Danielsen
Anders Haakonsson
Clifford J Rosen, Maine Medical CenterFollow
Moustapha Kassem

Document Type

Article

Publication Date

1-1-2019

Institution/Department

Center for Molecular Medicine, Maine Medical Center Research Institute

Journal Title

Bone Res

MeSH Headings

Mice, Animals, Bone Marrow, Mesenchymal Stem Cells, Cell Differentiation

Abstract

Enhanced bone marrow adipogenesis and impaired osteoblastogenesis have been observed in obesity, suggesting that the metabolic microenvironment regulates bone marrow adipocyte and osteoblast progenitor differentiation fate. To determine the molecular mechanisms, we studied two immortalized murine cell lines of adipocyte or osteoblast progenitors (BMSCs

ISSN

2095-4700

First Page

35

Last Page

35

Recommended Citation

Tencerova, Michaela; Rendina-Ruedy, Elizabeth; Neess, Ditte; Færgeman, Nils; Figeac, Florence; Ali, Dalia; Danielsen, Morten; Haakonsson, Anders; Rosen, Clifford J; and Kassem, Moustapha, "Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells." (2019). Maine Medical Center. 1547.
https://knowledgeconnection.mainehealth.org/mmc/1547