Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells.
Document Type
Article
Publication Date
1-1-2019
Institution/Department
Center for Molecular Medicine; Maine Medical Center Research Institute
Journal Title
Bone Res
MeSH Headings
Mice, Animals, Bone Marrow, Mesenchymal Stem Cells, Cell Differentiation
Abstract
Enhanced bone marrow adipogenesis and impaired osteoblastogenesis have been observed in obesity, suggesting that the metabolic microenvironment regulates bone marrow adipocyte and osteoblast progenitor differentiation fate. To determine the molecular mechanisms, we studied two immortalized murine cell lines of adipocyte or osteoblast progenitors (BMSCs
ISSN
2095-4700
First Page
35
Last Page
35
Recommended Citation
Tencerova, Michaela; Rendina-Ruedy, Elizabeth; Neess, Ditte; Færgeman, Nils; Figeac, Florence; Ali, Dalia; Danielsen, Morten; Haakonsson, Anders; Rosen, Clifford J; and Kassem, Moustapha, "Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells." (2019). MaineHealth Maine Medical Center. 1547.
https://knowledgeconnection.mainehealth.org/mmc/1547