Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells.
Center for Molecular Medicine, Maine Medical Center Research Institute
Mice, Animals, Bone Marrow, Mesenchymal Stem Cells, Cell Differentiation
Enhanced bone marrow adipogenesis and impaired osteoblastogenesis have been observed in obesity, suggesting that the metabolic microenvironment regulates bone marrow adipocyte and osteoblast progenitor differentiation fate. To determine the molecular mechanisms, we studied two immortalized murine cell lines of adipocyte or osteoblast progenitors (BMSCs
Tencerova, Michaela; Rendina-Ruedy, Elizabeth; Neess, Ditte; Færgeman, Nils; Figeac, Florence; Ali, Dalia; Danielsen, Morten; Haakonsson, Anders; Rosen, Clifford J; and Kassem, Moustapha, "Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells." (2019). Maine Medical Center. 1547.