Hemodynamics and Subclinical Leaflet Thrombosis in Low-Risk Patients Undergoing Transcatheter Aortic Valve Replacement.
Document Type
Article
Publication Date
12-1-2019
Institution/Department
Cardiology
Journal Title
Circ Cardiovasc Imaging
MeSH Headings
Humans, Transcatheter Aortic Valve Replacement, Thrombosis, Hemodynamics
Abstract
BACKGROUND: This analysis evaluated echocardiographic predictors of hypoattenuated leaflet thickening (HALT) in low-risk patients undergoing transcatheter aortic valve replacement and assessed 1-year clinical and hemodynamic consequences. HALT by computed tomography may be associated with early valve degeneration and increased neurological events.
METHODS: Echocardiograms were performed at baseline, discharge, 30 days, and 1 year post-procedure. Four-dimensional contrast-enhanced computed tomography assessed HALT at 30 days. Independent core laboratories analyzed images. Doppler hemodynamic parameters were tested in a univariable regression model to identify HALT predictors. One-year clinical and hemodynamic outcomes were compared between HALT (+) and (-) patients.
RESULTS: Analysis included 170 patients with Sapien 3 valves and diagnostic 30-day computed tomographies, of whom 27 (16%) had HALT. Baseline characteristics were similar between groups. After transcatheter aortic valve replacement, aortic flow was nonsignificantly reduced in patients who developed HALT. Regression analysis did not show significant association between baseline or discharge valve hemodynamics and development of HALT at 30 days. Patients with HALT had smaller aortic valve areas (1.4±0.4 versus 1.7±0.5 cm
CONCLUSIONS: There were no early hemodynamic predictors of HALT. At 30 days, patients with HALT had worse valve hemodynamics than those without HALT, but hemodynamic and clinical outcomes at 1 year were similar.
CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02628899.
ISSN
1942-0080
First Page
009608
Last Page
009608
Recommended Citation
Khan, Jaffar M; Rogers, Toby; Waksman, Ron; Torguson, Rebecca; Weissman, Gaby; Medvedofsky, Diego; Craig, Paige E; Zhang, Cheng; Gordon, Paul; Ehsan, Afshin; Wilson, Sean R; Goncalves, John; Levitt, Robert; Hahn, Chiwon; Parikh, Puja; Bilfinger, Thomas; Butzel, David; Buchanan, Scott; Hanna, Nicholas; Garrett, Robert; Shults, Christian; Garcia-Garcia, Hector M; Kolm, Paul; Satler, Lowell F; Buchbinder, Maurice; Ben-Dor, Itsik; and Asch, Federico M, "Hemodynamics and Subclinical Leaflet Thrombosis in Low-Risk Patients Undergoing Transcatheter Aortic Valve Replacement." (2019). MaineHealth Maine Medical Center. 1650.
https://knowledgeconnection.mainehealth.org/mmc/1650