Insulin-like growth factors: actions on the skeleton.

Document Type

Article

Publication Date

7-1-2018

Institution/Department

Maine Medical Center Research Institute

Journal Title

Journal of molecular endocrinology

MeSH Headings

Animals, Chondrocytes, Humans, Osteoblasts, Osteoclasts, Skeleton, Somatomedins

Abstract

The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins), insulin-like growth factor (IGF)-I and -II, has elicited an enormous interest primarily among endocrinologists who study growth and metabolism. The advancement of molecular endocrinology over the past four decades enables investigators to re-examine and refine the established somatomedin hypothesis. Specifically, gene deletions, transgene overexpression or more recently, cell-specific gene-ablations, have enabled investigators to study the effects of the

ISSN

1479-6813

First Page

115

Last Page

115

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