Insulin-like growth factors: actions on the skeleton.
Maine Medical Center Research Institute
Journal of molecular endocrinology
Animals, Chondrocytes, Humans, Osteoblasts, Osteoclasts, Skeleton, Somatomedins
The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins), insulin-like growth factor (IGF)-I and -II, has elicited an enormous interest primarily among endocrinologists who study growth and metabolism. The advancement of molecular endocrinology over the past four decades enables investigators to re-examine and refine the established somatomedin hypothesis. Specifically, gene deletions, transgene overexpression or more recently, cell-specific gene-ablations, have enabled investigators to study the effects of the
Yakar, Shoshana; Werner, Haim; and Rosen, Clifford J, "Insulin-like growth factors: actions on the skeleton." (2018). Maine Medical Center. 1702.